In the United States, the individual states or jurisdictions have the privilege to establish their own qualifications, rules, and regulations for professional licensure. Although each state has a Dental Board, the amount of independence differs from one Board to another. The majority of these Boards are often operative within other government branches, while specific Board members are normally appointed to that position by the state governor. In general, regulations and standards for licensure are determined by statute and can only be altered by proper proceedings within the state governing body. The wide variation that exists between the State Dental Boards often leads to confusion and frustration. Presented as a useful professional tool, this guide provides a Board-by-Board summary of dental anesthesia guidelines, rules, and regulations, across the dental profession.